WHAT CAUSES HAIR LOSS?
현대인에게 나타나는 탈모 증상은 점차 증가하고 있으며 그 원인은 매우 다양합니다. 국내 인구 중 다섯 명 중 한 명은 탈모로 고민하고 있으며, 탈모 제품 사용자들의 연령대도 낮아지고 있습니다. 탈모의 원인에 대해서는 유전적 요인 뿐만 아니라 다양한 원인에서 발생된다고 알려져 있습니다. 특히, 많은 남성들의 경우 남성 호르몬 테스토스테론이 환원효소에 의해 DHT로 변하고 이것이 모낭을 공격해 모발의 성장시간을 단축시키면서 탈모가 진행됩니다. 최근, 이러한 환원효소의 활동을 위축시켜 탈모 진행을 완화시키는 추출물에 대한 연구가 많이 진행되고 있습니다. 또한 스트레스, 불규칙한 생활, 과도학 화학 염료의 사용 그리고 환경호르몬 등 외부적 요인도 탈모의 원인이 됩니다. 과학기술의 발전과 함께 탈모 증상을 완화하는 수많은 제품들이 출시되고 있으나 탈모 제품에 대한 만족도는 13.5%에 불과합니다(한국 소비자원, 2016).
HAIR LOSS PRECESS
모낭을 공격, 모낭의 크기를 위축시킨다.
위축된 모낭은 모발이 자라는
기간을 단축시키면서 탈모가 진행된다.
탈모가 진행된 모발은
두께가 얇고 색이 옅으며 짧다.
Baicalin, a flavonoid, affects the activity of human dermal papilla cells and promotes anagen induction in mice.
2 August 2018, by Shin SH1, Bak SS, Kim MK, Sung YK, Kim JC.
Baicalin, a flavonoid isolated from Scutellaria baicalensis, is known to have multiple biological functions. Recent studies have demonstrated that baicalin treatment increases alkaline phosphatase activity (ALP) and osteoprotegerin secretion by osteoblasts. Furthermore, baicalin induces the differentiation of cultured osteoblasts via the activation of the Wnt/β-catenin signaling pathway. In this study, we evaluated the hair growth-promoting effects of baicalin in human follicular dermal papilla (DP) cells. A reporter assay and Western blotting were used to assess the effect of baicalin on β-catenin signaling in DP cells. ALP activity and messenger RNA (mRNA) expression were examined by ALP staining and real-time polymerase chain reaction (PCR), respectively. Growth factor expression levels were also evaluated using real-time PCR. Finally, the effect of baicalin on hair growth in vivo was examined by topical application of baicalin on the shaved dorsal skin of C57BL/6 mice.
Effects of Tocotrienol Supplementation on Hair Growth in Human Volunteers
Lim Ai Beoy,1 Wong Jia Woei,2 and Yuen Kah Hay1,*
Studies have shown an association between oxidative stress and alopecia. Patients with alopecia generally exhibit lower levels of antioxidants in their scalp area as well as a higher lipid peroxidation index. Tocotrienols belong to the vitamin E family and are known to be potent antioxidants. Hence, a study was conducted to investigate the effect of tocotrienol supplementation on hair growth in volunteers suffering from hair loss. Twenty one volunteers were randomly assigned to orally receive 100 mg of mixed tocotrienols daily while 17 volunteers were assigned to receive placebo capsule orally. The volunteers were monitored for the number of hairs in a pre-determined scalp area as well as the weight of 20 strands of 1 cm length hair clippings at 0 (before supplementation), 4 and 8 months. The number of hairs of the volunteers in the tocotrienol supplementation group increased significantly as compared to the placebo group, with the former recording a 34.5% increase at the end of the 8-month supplementation as compared to a 0.1% decrease for the latter. Nevertheless, the cumulative weight of 20 strands of hair clippings did not differ much from the baseline for both supplementation groups at the end of the study period.
The promotion of hair regrowth by topical application of a Perilla frutescens extract through increased cell viability and antagonism of testosterone and dihydrotestosterone.
Li JJ1, Li Z2, Gu LJ3, Choi KJ3, Kim DS4, Kim HK5, Sung CK6.
This study investigated the potential hair regrowth effects associated with a plant extract of Perilla frutescens, which was selected due to its putative hair regrowth activity. Extracts were prepared from dried P. frutescens suspended in distilled water, where the resultant aqueous suspension was fractionated sequentially using hexane, ethyl acetate, n-butanol, and distilled water. We observed that the n-butanol fraction resulted in the highest hair regrowth activity. The n-butanol soluble fraction of P. frutescens extract (BFPE) was further separated using AB-8 macroporous resin and silica gel chromatography to obtain rosmarinic acid (RA), which demonstrated effective hair growth regeneration potential. BFPE also showed in vivo anti-androgenic activity following the use of a hair growth assay in testosterone-sensitive male C57Bl/6NCrSlc mice. Furthermore, the effects of cell viability promotion were investigated following an in vitro analysis in primary hair follicle fibroblast cells (PHFCs) treated with RA. The results suggested that RA was the active compound in P. frutescens that triggers hair growth, and RA could be a potential therapeutic agent for the promotion of hair growth and prevention of androgenetic alopecia (AGA).